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In his "Overture to the Subversive Proposal," Stevan Harnad Cognitive Scientist, University of Southampton writes, "For centuries, it was only out of reluctant necessity that authors of esoteric publications entered into the Faustian Bargain of allowing a price tag to be erected as a barrier between their work and its intended readership, for that was the only way they could make their work public at all during the age when paper publication was their only option.

The collection, maintenance and dissemination of these data will be more costly than printing, but the information will be much more valuable to the scientific community. Of course, when we get to this point we won't be publishing journals; the output will be called something else. Scholarly Journals at the Crossroads makes publishing history.

It is the first time that a book derived from a series of wide-ranging Internet discussions on a scholarly topic recreates insofar as possible an e-mail experience for a general academic and publishing audience. In their Conclusion, Ann Okerson ARL and James O'Donnell Professor of Classics, University of Pennsylvania , the editors of this 9-month long networked conversation write, "This is a book about hope and imagination in one corner of the emerging landscape of cyberspace.

It embraces passionate discussion of an idea for taking to the Internet to revolutionize one piece of the world of publishing. The Association of Research Libraries is a not-for-profit organization representing research libraries in the United States and Canada. Its mission is to shape and influence forces affecting the future of research libraries in the process of scholarly communication. ARL programs and services promote equitable access to, and effective use of recorded knowledge in support of teaching, research, scholarship, and community service.

These programs include annual statistical publications, federal relations and information policy, and enhancing access to scholarly information resources through telecommunications, collection development, preservation, and bibliographic control. The Office of Scientific and Academic Publishing works to identify and influence the forces affecting the production, dissemination, and use of scholarly and scientific information. The book is produced in 7 x 10 format, paperbound, in pages.

Its ISBN number is: The raw source files from which the Subversive Book is derived can be found on the Internet as follows: ftp to the site ftp. Proposal To contact the editors: Ann Okerson ann cni. But of course a lot of restructuring goes with going electronic only, and in the process many paper line-items like subscription and fulfillment, and, to be fair, all overheads from any parallel paleolithic paper operations vanish.

Instead of continuing to do these abstract calculations, why not just get the real data from the actual editorial offices of the small but growing fleet of brave new e-only journals? She also edits the annually updated Directory of Electronic Journals.

The email addresses of all the editorial offices are contained therein. Another suggestion: Why not archive the hyperjournal-forum discussion as a Hypermail Archive on the Hypermail Home Page? All the list owner needs to do is to save all the postings in a unix mail file, with headers. The Hypermail sofware does all the rest. My understanding is that it is a group of libraries that formed a consortia for the purpose of purchasing electronic journals at a discounted rate.

They may be based at Johns Hokins, but the information I have is sketchy, and my queries via veronica and other internet resources garnered nothing. I have also check the American Library Directory and Library Literature, but I have been unable to locate any information. If you have any information about this project, I would greatly appreciate your contacting me privately via email.

Thank you in advance for any information you can provide. OK, I'll bite. I would so much like to hear some real numbers that I now am asking about the operating budget of Psycoloquy. Perhaps then we all can compare that itemization to our own working budgets - those of us in the print world.

Or is there a large subsidy behind that number? Trust me, if this can be proven through actual working examples, I - and most likely several others - will be converted to this model. It is really the time to pass these 'abstract calculations' and hear from those who are producing e-journals about the 'real' costs involved. JHU's system boasts several interesting features: hypertext bibliographies, a search engine, a convenient and straightforward approach to subscriptions and licensing, and more.

You can find out more at JHU's Web site; look under the icon for the university's libraries. Glad you asked. No secret hidden subsidies so far! But Psycoloquy is atypical for one specific reason, so not the right journal on which to base extrapolations: It is a journal of Open Peer Commentary.

Most journals are not. If an article is accepted, there is a call for multiple commentary. One day it may be possible to compare, but not yet. The comparison now would be flattering to Psycoloquy, but meaningless because of the scale differences.

I think the best comparisons will be with conventional journals with comparable subject matter, submission rates, acceptance rates, annual article quotas, and readership. To be most informative, they should also be equal in number of years of publication, so new journals are compared with new journals, where start-up costs can be compared, and low initial volume can be equated.

So far, I think some of the new maths and computer science elecectronic journals are in the best position to provide data for comparing with their paper homologues, but there may be others. Comparing Psycoloquy to BBS at this point would really be misleading. I might add that Psycoloquy's budget is about to grow a bit, in order to set up a system to hypertextify it.

That will be in the category of temporary seeding costs, however, rather than long-term costs. The breakdown of Psycoloquy's 15K subsidy from the American Psychological Association is easy: It all goes into paying Editorial Assistants and Copy Editors to 1 handle the refereeing correspondence, 2 copy edit and format accepted articles, and 3 maintain the listserv version.

With the hypertextification grant, there will also be the cost of 4 html mark-up. Harris by way of horn pobox. Please test this compact publishing framework, download from CompuServe. At this meeting, the second of our two meetings at the conference, we will be discussing what we should be doing at future meetings: what aspects of the subject "serials standards" should be discussed?

Your input is not only wanted, but needed! If you wish to attend the meeting and share your ideas, you will be a welcome participant. If you have ideas but will not be at the meeting, please send them to me via E-mail and I will bring them to the meeting on your behalf.

Please remember to reply directly to me, not to whatever list you are reading!!! E McCormick Place There are many projects developing prototypes of the digital library and these projects are the subject of several programs at ALA. But how do these projects relate to your needs? Do they address the questions you have? What are those questions? In this session, you will have the opportunity to talk about these issues in a group of people. After half an hour, the small groups will share their list of questions with the entire group.

Come ready to participate in what promises to be a fruitful discussion. Note: a compilation of the group's questions will be posted to these lists following ALA. Is it possible to do it with 10 hours per week of clerical effort and 5 hours a week of a professional's time? And frankly, I won't be convinced by numbers from the "actual editorial offices of the small but growing fleet of brave new e-only journals If a bus runs over the editor, will the journal survive?

The conference proceedings are intended to be published on flopy disc. Orczan [chair] Zsolt Orczan Dr [co-chair orczanz mars. Please note that for early registration a reduced fee is applicable. You will receive the confirmation of your participation and the detailed program in due time. I intend to submit a paper Technical equipment required I pay the fee MoneyGram I register Please send me information about available accomodations Please inform me about Excursion, Theatre, or Opera Of what he saw there he wrote as follows: "Buda with its blue chain of hills, Pest with its yellow plain, and the majestic Danube with its green isles were all sprawled out at our feet One hundred and fifty years have passed since the ousting of the Turk, and in this space of time, the city has risen from squalid ruins to become one of the great cities of Europe.

The Doctor draws Teeth without pulling off your Mask. James's Coffee-house, either by miscalling the Servants, or requiring such things from them as are not properly within their respective Provinces; this is to give Notice, that Kidney, Keeper of the Book-Debts of the outlying Customers, and Observer of those who go off without paying, having resigned that Employment, is succeeded by John Sowton; to whose Place of Enterer of Messages and first Coffee-Grinder, William Bird is promoted; and Samuel Burdock comes as Shooe-Cleaner in the Room of the said Bird.

They are not only instructed to pronounce Words distinctly, and in a proper Tone and Accent, but to speak the Language with great Purity and Volubility of Tongue, together with all the fashionable Phrases and Compliments now in use either at Tea-Tables or visiting Days. Those that have good Voices may be taught to sing the newest Opera-Airs, and, if requir'd, to speak either Italian or French, paying something extraordinary above the common Rates.

They whose Friends are not able to pay the full Prices may be taken as Half-boarders. She teaches such as are design'd for the Diversion of the Publick, and to act in enchanted Woods on the Theatres, by the Great. As she has often observ'd with much Concern how indecent an Education is usually given these innocent Creatures, which in some Measure is owing to their being plac'd in Rooms next the Street, where, to the great Offence of chaste and tender Ears, they learn Ribaldry, obscene Songs, and immodest Expressions from Passengers and idle People, and also to cry Fish and Card-matches, with other useless Parts of Learning to Birds who have rich Friends, she has fitted up proper and neat Apartments for them in the back Part of her said House; where she suffers none to approach them but her self, and a Servant Maid who is deaf and dumb, and whom she provided on purpose to prepare their Food and cleanse their Cages; having found by long Experience how hard a thing it is for those to keep Silence who have the Use of Speech, and the Dangers her Scholars are expos'd to by the strong Impressions that are made by harsh Sounds and vulgar Dialects.

In short, if they are Birds of any Parts or Capacity, she will undertake to render them so accomplish'd in the Compass of a Twelve-month, that they shall be fit Conversation for such Ladies as love to chuse their Friends and Companions out of this Species. Powell, as sometimes raising himself Applause from the ill Taste of an Audience; I must do him the Justice to own, that he is excellently formed for a Tragoedian, and, when he pleases, deserves the Admiration of the best Judges; as I doubt not but he will in the Conquest of Mexico, which is acted for his own Benefit To-morrow Night.

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Fast indexing! Within a month, there is a natural increase in backlinks. I am always in touch, you can ask me a question if you have any questions. Website promotion is inexpensive with a quality guarantee, hurry up!! Team 1 — Thanks for a great presentation. Although I did not sign up for the various social media accounts for personal and professional reasons, your presentation allowed me to learn more about three social media platforms.

Your last paragraph is really insightful and it ties to a previous discussion we had in the Entrepreneur Bootcamp. Social media was mainly developed as a connection tool, not as a tool for PD. Zaznacz wszystko. Analityczne dostawcy oprogramowania. Dodano: w kategorii: - autor: admin. Komentarze do wpisu Annasysgoolf 2 czerwca Annasysgoolf 7 czerwca Annasysgoolf 9 czerwca Carlosgub 19 czerwca Carlosgub 20 czerwca Carlosgub 21 czerwca Carlosgub 22 czerwca Carlosgub 23 czerwca Carlosgub 25 czerwca Carlosgub 26 czerwca Shubertrtenemi 26 czerwca Carlosgub 27 czerwca Carlosgub 28 czerwca EdwardGepsy 23 lipca Robertplume 23 lipca The one-year prevalence of Migraine that reduces activity was 8.

Females tend to suffer more from migraines and TTH as well as ages The average patients has been suffering from headaches for 12 years. Headaches typically occur once a month or more frequently, 8 days per month on average. Although patients rarely misss work due to headaches, they do report headache-induced reductions in performance around 3 days per month. About one fifth of patients seek professional treatment for headaches, most of them in the private sector.

The most popular specialty for headache treatment is neurologist, followed by internist. Regarding both prophylactic and acute treatment, patients prefer oral medication to injection, even if the former is administered more frequently.

The stimulation device seems to be more attractive to males. Painkillers also are by far the most common acute treatment for headaches and the vast majority of patients have never taken prophylaxis for headaches. Only a small fraction have stopped taking a prophylactic treatment due to adverse effects. Calcitonin gene-related peptide CGRP , a neuropeptide previously known only by specialists interested in neurogenic inflammation, is now discussed throughout the communities of migraine researchers, headache therapists and even migraine patients.

The reason for this surprising career of CGRP awareness is evident. CGRP is the main neuropeptide of a major part of nociceptive trigeminal afferents and is released upon their activation. Thus CGRP release is characteristic, though in no way specific, for the trigeminovascular system, which is regarded as the structural basis for headache generation.

In fact, CGRP has been found at elevated concentrations in the cranial outflow during attacks of migraine and some trigemino-autonomic headaches; infusion of CGRP into patients suffering from primary headaches can cause head pain mimicking their spontaneous headache attacks; inhibiting CGRP or its receptors or its release can be preventive or therapeutic in those types of primary headaches. However, looking behind the curtain of impressive significance of this biomarker, broad gaps in our knowledge are visible concerning the sites of CGRP release, its flow through the meningeal compartments, the sites and mechanisms of actions and its elimination.

With preclinical experiments we are only at the beginning to study these issues, which are increasingly important in the light of new pharmacological developments targeting CGRP and its receptors by antagonists or monoclonal antibodies, and keeping in mind possible risks of a long-term treatment with these substances.

Trigeminal activity controlled by CGRP receptor activation could indeed be a pivot point in headache generation and therapy. However, measurable circulating concentrations of CGRP are far too low to explain any receptor effects, while it is difficult to assess its real concentrations near the likely release sites, namely the meningeal terminals of trigeminal afferents, the trigeminal ganglion and the central terminals in the trigemino-cervical brainstem complex.

The central effects of CGRP as a synaptic neuromodulator could explain neuronal CGRP effects to some extent but big molecules like monoclonal antibodies are unlikely to pass the blood-brain barrier and may not be able to act there.

Peripheral effects of CGRP are largely confined to its well-known vascular functions, while fast neuronal effects are not established so far in the trigeminal system. The trigeminal ganglion is a possible point of CGRP action but only few experiments have shown an impact on the signalling or metabolic changes of ganglion neurons.

Therefore new experimental approaches are needed to uncover the secrets of the nociceptive CGRP signalling system and its therapeutic control. Medical management of headache disorders, for the vast majority of people affected by them, can and should be carried out in primary care. It does not require specialist skills. Nonetheless, it is recognised that non-specialists throughout Europe may have received limited training in the diagnosis and treatment of headache.

This publication, in the Journal of Headache and Pain , provides a combination of educational materials and practical management aids. It is a product of the Global Campaign against Headache, a programme of action for the benefit of people with headache conducted by the UK-registered non-governmental organization Lifting The Burden LTB in official relations with the World Health Organization.

It updates the first edition [1], published 10 years ago. It has undergone review by a wider consultation group of headache experts, including representatives of the member national societies of EHF, primary-care physicians from eight countries of Europe, and lay advocates from the European Headache Alliance.

While the focus is Europe, the inclusion in the consultation group of members from all six world regions has aimed for cross-cultural relevance of all content so that it is useful to a much wider population.

The European principles of management of headache disorders in primary care , laid out in 11 sections, are the core of the content. Each of these is more-or-less stand-alone, in order to act as practical management aids as well as educational resources. There is a set of additional practical management aids.

An abbreviated version of the International Classification of Headache Disorders, 3rd edition ICHD-3 , provides diagnostic criteria for the few headache disorders relevant to primary care.

A headache diary further assists diagnosis and a headache calendar assists follow-up. A measure of headache impact the HALT index can be employed in pre-treatment assessment of illness severity, and an outcome measure the HURT questionnaire is a guide to follow-up and need for treatment-review. Five patient information leaflets are included, which may be offered to patients to improve their understanding of their headache disorders and their management.

We hope for benefits for both physicians and patients. Several data indicate that migraine, especially migraine with aura, is associated with an increased risk of ischemic stroke and other vascular events.

Of concern is whether the risk of ischemic stroke in migraineurs is magnified by the use of hormonal contraceptives HCs. As migraine prevalence is high in women of reproductive age, it is common to face the issue of migraine and HC use in clinical practice. The document pointed out that evidence addressing the risk of ischemic stroke associated with the use of HCs is generally poor. All information relies on observational data, which may carry the risk of potential bias.

Available studies had different settings and used different groups for comparing risks, limiting reliable comparison of studies as a pooled analysis of data. Most of the available studies were published several years ago and used compounds which are different from those available today. Additionally, in most studies not enough information is available regarding the type of HC considered and in most cases results are not provided according to migraine type.

Despite those limitations, available data pointed toward an increased risk of ischemic stroke associated with the use of HCs in women with migraine. Literature indicated that, whereas combined HCs carry a certain risk of arterial ischemic events this does not happen for progestogens-only HCs which are considered safe in terms of cardiovascular risk even in the presence of associated risk factors. Considering those data, and unless studies will prove safety of the use of combined HCs in women with migraine, the recommendations from the Consensus Group gave priority to safety and suggested several limitations in the use of combined HCs in women with migraine.

There are alternative methods to combined HCs which provide similar contraceptive benefits but that are much safer in terms of risks. Further research is need to address safety of newer compounds in women with migraine. J Headache Pain ;in press. Neuropathic pain is pain caused by a lesion or disease of the somatosensory nervous system. The term lesion is refers to nervous system damage demonstrated by imaging, neurophysiology, biopsies or surgical evidence.

The term disease is used when the nervous system damage is due to a neurological disorder such as stroke or peripheral diabetes neuropathy. In peripheral neuropathic pain there is usually a mixture of damaged and undamaged axons within the peripheral nerve, leading to the clinical presentation with ongoing pain, sensory loss and sensory gain hyperalgesia, allodynia.

The clinical presentation in central neuropathic pain is similar, but the mechanisms are less well understood. Mechanisms of peripheral neuropathic pain include ectopic impulse generation, peripheral sensitization of undamaged nerve fibers, and central sensitization; the latter includes altered signal processing in the CNS due to changes in descending pain modulation. For this reason the exact prevalence of neuropathic pain is not yet known, but is expected to be high due to the high prevalence of the underlying neurological disorders.

A range of clinical neurophysiological and functional imaging studies have suggested that migraine might be associated with cerebellar dysfunction. These studies all had methodological short-comings to a greater or lesser extent. Therefore, it is still uncertain whether migraine is associated with cerebellar dysfunction, and, if so, to what extent and why. Recent anatomical studies demonstrated that the output of the cerebellum targets multiple non-motor areas in the prefrontal and posterior parietal cortex.

Neuro-anatomy and functions of the cerebellum will be reviewed as well as the evidence of cerebellar infarcts in migraineurs. During the last decades, the methods of neurophysiology proved to be very effective in disclosing subtle functional abnormalities of the brain of patients affected by primary headache disorders.

These methods received several refinements during the last years, further improving our understanding of headaches pathophysiology. Abnormal increased responsivity was several times revealed with almost all the sensory modalities of stimulation in migraine between attacks, with its normalization during the attacks.

Recently, authors observed that the degree of some neurophysiological abnormalities might depends on the distance from the last attack, i. Somatosensory cortex lateral inhibition, gating, and interhemispheric inhibition were altered in migraine, and may contribute to cortical hyperresponsivity and clinical features. Cluster headache patients are characterized by a deficient habituation of the brainstem blink reflex during the bout, outside of attacks, on the affected side.

Evidence for sensitization of pain processing was disclosed by studying temporal summation threshold of the nociceptive withdrawal reflex, which was less modulated by supraspinal descending inhibitory controls. In conclusion, much has been discovered and much more needs to be investigated to better understand what causes, how it triggers, keeps and runs out recurrent primary headaches.

Clarifying some of these mechanisms might help in the identification of new therapeutic targets. Within the brain, neuropeptides can modulate the strength of synaptic signaling even at a relatively large distance from their site of release. Given the evidence for CGRP in migraine and potential roles for other hypothalamic peptides, it seems likely that altered neuropeptide actions may be a general theme underlying the heightened sensory state of migraine. Towards this point, I will briefly discuss our preclinical CGRP and optogenetic studies using light aversive behavior in mouse models as a surrogate for migraine-associated photophobia.

I will describe how both the brain and the periphery are susceptible to elevated CGRP and how CGRP appears to act by distinct mechanisms in these sites. These ideas will be tied together in a speculative model that integrates peripheral and central CGRP actions in photophobia. Classical trigeminal neuralgia TN is a unique neuropathic facial pain disorder. As there are no diagnostic tests to confirm the diagnosis, it relies on a thorough history and exam.

MRI is used to exclude symptomatic trigeminal neuralgia, not to confirm the diagnosis of TN. Knowing how to interpret MRI findings is of importance with respect to surgical treatment options and their expected chance of a successful outcome. TN is characterized by paroxysms of unilateral intense pain usually in the 2 nd and 3 rd trigeminal branch.

The pain quality is stabbing and the pain is typically evoked by sensory stimuli like light touch, brushing teeth, cold wind or eating. Up to half of the patients also have concomitant persistent pain. A smaller proportion of patients may have sporadic autonomic symptoms. The average age of disease onset is in the early fifties and TN is slightly more prevalent in women than in men.

As a general rule, the neurological exam is normal in TN patients. As objective signs of TN, patients may wince at pain paroxysms and may avoid shaving or brushing their teeth on the affected side. Some studies argue that a proportion of TN patients have subtle sensory abnormalities at bedside exam, primarily hypoesthesia. Studies using quantitative sensory testing also documented sensory changes in TN.

Rather than indicating nerve damage, the findings may be explained by functional changes of the nervous system in response to severe pain. There is widespread consensus that TN is associated to a neurovascular contact between the trigeminal nerve and a blood vessel in the prepontine course of the nerve.

Emerging advanced imaging studies confirms that at the site of a neurovascular contact on the ipsilateral side of pain, there is of demyelination — a process that seems to be reversible in some patients after successful surgery.

Imaging studies also consistently show that TN is strongly associated to a neurovascular contact with morphological changes of the trigeminal nerve, i. Meanwhile, only half of TN patients have morphological changes of the trigeminal nerve and there may be other unknown etiological factors causing TN. The pearls and pitfalls of TN diagnosis and neuroimaging is discussed from both a clinical and a scientific perspective.

The first evidence for potential role of PACAP in pathomechanism of migraine was the intravenous administration of PACAP caused headache and vasodilatation in healthy subjects as well as in migraineurs, and lead to delayed-type migraine-like attacks [2]. Preclinical experiments revealed that both PACAP and PACAP were found elevated in the trigeminal nucleus caudalis of rats following electrical stimulation of the trigeminal ganglion or chemical stimulation by nitroglycerin of the trigeminovascular system [3].

A magnetic resonance imaging MRI angiographic study demonstrated that PACAPinduced headache was associated with prolonged dilatation of the middle meningeal arteries, but not of the middle cerebral arteries in healthy volunteers [4].

The recent functional imaging study pointed that intravenous PACAPinduced migraine attacks was associated with alterations in brain network connectivity [6]. Clinical investigation provided evidence of a clear association between migraine phases during a spontaneous migraine attack versus pain-free period and the alteration of plasma PACAP level [7].

The activation and sensitization of the trigeminovascular system by vasoactive neuropeptides might be crucial factors of the migraine pathogenesis [8].

The recent preclinical and clinical studies suggest the importance of PACAP as a future biomarker of migraine headache. Schytz, H. PACAP38 induces migraine-like attacks in patients with migraine without aura. Tuka, B. Peripheral and central alterations of pituitary adenylate cyclase activating polypeptide-like immunoreactivity in the rat in response to activation of the trigeminovascular system. Peptides ; Amin, F. Cephalalgia ; Investigation of the pathophysiological mechanisms of migraine attacks induced by pituitary adenylate cyclase-activating polypeptide Brain ; Neurology ; Alterations in PACAPlike immunoreactivity in the plasma during ictal and interictal periods of migraine patients.

Several studies are found a relationship between headache and psychiatric comorbidity in both children and adolescents []. The most frequently described comorbidities include anxiety, mood disorders [1], sleep disorder [2] and attention hyperactive disorder [3].

The association between headache and comorbidities has been interpreted in the light of different possible causal pathways. Psychiatric comorbidity may represent the consequence of a link between neurotransmitter systems involved in migraine and psychiatric disorder, such as depression and anxiety [4].

A central role is thought to be played by serotonergic receptors, adrenergic and dopaminergic D2 receptor genotype, that seem to be associated with migraine, major depression, generalized anxiety disorder, panic attacks and phobia [5]. It has been suggested that the patient's vulnerability to anxiety disorders and affective disorders as well as migraine might be attributed to the dysregulation of the serotonergic system [6].

Furthermore, it is possible that each disorder increases the risk of the other [4;7]. Therefore, the relevance of other mediating factors for the co-occurrence of headache and psychiatric comorbidity has to be taken into consideration.

Recent research found that an insecure attachment may be a risk factor for an outcome of poor adaptation that includes chronic pain [9] and that pain perception may change in relation with specific attachment styles. The ambivalent attachment seems to be the most common style among patients reporting high attack frequency and severe pain intensity and in children with this attachment style there is a relationship between high attack frequency and high anxiety levels [10].

Barone et al. Although more studies are needed in order to detect the biological, genetic and environmental mechanisms underlying the relationship between headache and comorbidities, attachment styles can be regarded as one of the factors mediating this association [12]. Anxiety, depression and behavioral problems among adolescents with recurrent headache: the Young-HUNT study.

The relationship between sleep and headache in children: implications for treatment. Headache and attention deficit and hyperactivity disorder in children: common condition with complex relation and disabling consequences. Epilepsy Behav. Migraine and psychiatric comorbidity: a review of clinical findings.

Mol Med. Association of 5-HTT gene polymorphisms with migraine: a systematic review and meta-analysis. J Neurol Sci ; : Headache and comorbidity in children and adolescents.

J Headache Pain ; Genetic and environmental influences on migraine: a twin study across six countries. Twin Res. Pain and emotion: a biopsychological review of recent research. J Clin Psychol ; 67 9 : Attachment styles in children affected by migraine without aura. Neuropsychiatr Dis Treat. Behavioural problems in children with headache and maternal stress: is children's attachment security a protective factor?

Dev ; DOI: The role of attachment insecurity in the emergence of anxiety symptoms in children and adolescents with migraine: an empirical study. J Headache Pain In Press. Metabolic syndrome and overweight are highly prevalent among migraineurs and the weight-loss was suggested as a useful strategy to improve both migraine and metabolic syndrome. Recently, we have observed that a particular version of VLCD characterized by very low-carbohydrate intake and Ketone bodies KBs production, named very low-calorie ketogenic diet VLCKD , was able to induce a rapid improvement of headache in migraineurs.

To assess if the favorable outcome on migraine was due to the caloric restriction, instead of KBs, we performed a double blind crossover study to compare headache modifications during a VLCD and a VLCKD in a population of overweighed and obese migraineurs. Among patients referred to the Sapienza University Obesity Clinic, a neurologist specializing in headache recruited 35 migraineurs. To verify variations in headache frequency, we used as baseline the month before the first VLCD and the first transition diet.

Headaches are one of the most disabling disorders [1]. Moreover, recent knowledge have suggested that physical examination for provocative procedures should be done on each patient with side- locked headaches as many of these headaches may closely mimic primary headaches [4].

There have been identified eleven physical tests to properly assess cervical disorders. When these dysfunctions are present, they support a reciprocal interaction between the trigeminal and the cervical systems as a trait symptom in migraine [6, 7]. In this presentation, an evidence based physical protocol of specific tests it will be provided by a physiotherapist to assess musculoskeletal disorders in the most common primary headaches as Migraine and Tension Type Headache.

Moreover, the integration of this examination in a multidisciplinary team it will be discussed. Stovner LJ. Migraine prophylaxis with drugs influencing the renin- angiotensin system.

Eur J Neurol. Prevalence of neck pain in migraine and tension-type headache: a population study. Temporomandibular disorders is more prevalent among patients with primary headaches in a tertiary outpatient clinic. Arq Neuropsiquiatr. Prakash S, Rathore C. Side-locked headache: an algorithm based approach. The Journal of Headache and Pain ; doi International consensus on the most useful physical examination tests used by physiotherapists for patients with headache: A Delphi study.

Man Ther. Musculoskeletal dysfunction in migraine patients. The International Classification of Headache Disorders, 3rd edition beta version Jul;33 9 Headache represents the most common neurological symptom in pediatric age. Among the primary headaches, migraine is far more prevalent than tension-type headache and cluster headache.

Though extremely rare at this age, also trigeminal autonomic cephalgias have been reported. The most frequent causes of pediatric secondary headaches are represented by respiratory tract infections, while potentially life-threatening diseases, such as brain tumors, are less common.

However, especially in the emergency setting, the possibility that a headache attack is due to a brain tumor must be always considered. To avoid missing these cases, some headache characteristics red flags have been identified [1].

However, while the most recent ICHD criteria improved the possibility to classify some patients, such as children with migraine with aura [2], they turned out to be unsuitable for others, such as young patients with primary headache. Several studies have shown the primary role played by psychological factors in determining the severity of migraine in children [4].

Therefore, a psychological examination is often mandatory, as part of the initial assessment of the patient. Lastly, when assessing a child with primary headache, possible comorbidities should be never forgotten, since addressing them can represent a crucial point for the treatment [5]. Headache as an emergency in children and adolescents. Curr Pain Headache Rep ; Cephalalgia, submitted.

Diagnosis of primary headache in children younger than 6 years: A clinical challenge. Cephalalgia ;

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